Studies - Research - Trials

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Arnica (Arnica montana)


Accelerated resolution of laser-induced bruising with topical 20% arnica: a rater-blinded randomized controlled trial.


Homeopathic arnica therapy in patients receiving knee surgery: results of three randomised double-blind trials.


Arnica montana gel in osteoarthritis of the knee: an open, multicenter clinical trial.


Bergamot (Citrus bergamia)


In vitro protective effects of two extracts from bergamot peels on human endothelial cells exposed to tumor necrosis factor-alpha (TNF-alpha).


Intraplantar injection of bergamot essential oil into the mouse hindpaw: effects on capsaicin-induced nociceptive behaviors.



Calendula (Calendula officinalis)


Wound Healing and Anti-Inflammatory Effect in Animal Models of Calendula officinalis L. Growing in Brazil.


Determination of the wound healing effect of Calendula extracts using the scratch assay with 3T3 fibroblasts.


Importance of local skin treatments during radiotherapy for prevention and treatment of radio-induced epithelitis


Improved anti-inflammatory activity of three new terpenoids derived, by systematic chemical modifications, from the abundant triterpenes of the flowery plant Calendula officinalis.


Anti-inflammatory, anti-tumor-promoting, and cytotoxic activities of constituents of marigold (Calendula officinalis) flowers.


Cannabis (Cannabis sativa L.)


Topical cannabinoid agonists. An effective new possibility for treating chronic pruritus.


Adjuvant topical therapy with a cannabinoid receptor agonist in facial postherpetic neuralgia.


Cannabidiol-transdermal delivery and anti-inflammatory effect in a murine model.


Anti-inflammatory activity of topical THC in DNFB-mediated mouse allergic contact dermatitis independent of CB1 and CB2 receptors.


Local delivery of cannabinoid-loaded microparticles inhibits tumor growth in a murine xenograft model of glioblastoma multiforme.


Cannabinoid agonists attenuate capsaicin-induced responses in human skin.



Comfrey (Symphytum)


Comfrey root: from tradition to modern clinical trials.


Comfrey: a clinical overview.


Comfrey extract ointment in comparison to diclofenac gel in the treatment of acute unilateral ankle sprains (distortions).


Efficacy of a comfrey root (Symphyti offic. radix) extract ointment in the treatment of patients with painful osteoarthritis of the knee: results of a double-blind, randomised, bicenter, placebo-controlled trial.


Topical symphytum herb concentrate cream against myalgia: a randomized controlled double-blind clinical study.


Efficacy and tolerance of a comfrey root extract (Extr. Rad. Symphyti) in the treatment of ankle distorsions: results of a multicenter, randomized, placebo-controlled, double-blind study.


Therapeutic characteristance and tolerance of topical comfrey preparations. Results of an observational study of patients.


Rose Hips Seed (Rosa canina)


A systematic review on the Rosa canina effect and efficacy profiles.


St. John's wort (Hypericum perforatum)


Topical application of St. John's wort (Hypericum perforatum).


Hypericum perforatum L. subsp. perforatum induces inhibition of free radicals and enhanced phototoxicity in human melanoma cells under ultraviolet light.


Estimation of dermatological application of creams with St. John's Wort oil extracts.


Analgesic and topical anti-inflammatory activity of Hypericum canariense L. and Hypericum glandulosum Ait.


Topical treatment of atopic dermatitis with St. John's wort cream--a randomized, placebo controlled, double blind half-side comparison.


Topical application of St John's wort (Hypericum perforatum L.) and of its metabolite hyperforin inhibits the allostimulatory capacity of epidermal cells.


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